Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester

Participants

Reaction Steps

4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.

Provenance & Evidence