Hydrochloric Acid → HCID 57983479, compound

Participants

Reaction Steps

Methyl N-((6-chloro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)-D-alaninate (75 mg, 213 μmol) was dissolved in THF (2132 μL). 5N NaOH in water (2132 μL, 10660 μmol) was added at ambient temperature, and the reaction was stirred for 3 hours. The reaction mixture was acidified with 3N HCl, diluted with 50 mL of EtOAc, added to a separatory funnel, washed 2 times with 20 mL of brine (saturated, aqueous), separated, dried over Na2SO4, and concentrated to give the title compound as a white amorphous solid. MS m/e 338 (M+H)+. Calculated for C16H16ClNO5 337.07.

Provenance & Evidence