HCID 67099779, compound → HCID 67100171, compound

Participants

Reaction Conditions

Reaction Steps

To 10 mL concentrated H2SO4 stirred at 0° C. was added diethyl 2-(4-(2,3-difluorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate (3.3 g, 8.6 mmol) dropwise. The mixture was stirred at 0° C. and allowed to warm to room temperature over 2 hours. The mixture was poured into 100 g crushed ice and extracted with EtOAc (3×100 mL). The combined organic layers were washed with saturated NaCl (20 mL), dried over anhydrous Na2SO4, concentrated in vacuo, and purified by column chromatography (20% EtOAc/hexane) to give the title compound 0.23 g as a pale yellow solid. MS m/e: (M+H)+ 339.

Provenance & Evidence