HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 3-(beta-D-Glucopyranosyloxy)-4-[(4-(3-[3-(2-hydroxyethyl)ureido]propoxy)-2-methylphenyl)methyl]-5-isopropyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 2-Morpholinoethylamine | HCID 408285 | — |
| Reactant | 3-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy)-4-{[4-(3-aminopropoxy)-2-methylphenyl]-methyl}-5-isopropyl-1H-pyrazole | HCID 68940120 | — |
| Product | 3-(beta-D-Glucopyranosyloxy)-4-[(4-(3-[3-(2-hydroxyethyl)ureido]propoxy)-2-methylphenyl)methyl]-5-isopropyl-1H-pyrazole | HCID 68940523 | — |
Reaction Steps
The title compound was prepared in a similar manner to that described in Example 19 using 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-{[4-(3-aminopropoxy)-2-methylphenyl]methyl}-5-isopropyl-1H-pyrazole and 2-aminoethanol instead of 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-{[4-(3-aminopropoxy)phenyl]methyl}-5-isopropyl-1H-pyrazole and 4-(2-aminoethyl)morpholine, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07635684B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-aedbe72e4a1f433c854a9df4f790f873 |
| Source note | uspto-grants-2009_12 |