HRID1869005

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：Cc1cc(OCCCN[C@@H](CCCCNC(=O)OCc2ccccc2)C(N)=O)ccc1Cc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)n[nH]c1C(C)C

HCID68941036

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1cc(OCCCN[C@@H](CCCCN)C(N)=O)ccc1Cc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)n[nH]c1C(C)C

HCID10416055

未命名化合物

收率 93.7%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 4-[(4-{3-[(S)-5-benzyloxycarbonylamino-1-(carbamoyl)pentylamino]propoxy}-2-methylphenyl)-methyl]-3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole (0.17 g) in methanol (4 mL) was added 10% palladium-carbon powder (30 mg), and the mixture was stirred at room temperature under a hydrogen atmosphere for 1 hour. The insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (0.13 g).

WORKUP

后处理

customThe insoluble material was removed by filtration
concentrationthe filtrate was concentrated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-e8d858f372a243b1b35b9cef75f47297
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07635684B2
来源说明: uspto-grants-2009_12

反应SMILES

C(OC([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:20][CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]2[C:33]([O:40][C@@H:41]3[O:49][C@H:48]([CH2:50][OH:51])[C@@H:46]([OH:47])[C@H:44]([OH:45])[C@H:42]3[OH:43])=[N:34][NH:35][C:36]=2[CH:37]([CH3:39])[CH3:38])=[C:27]([CH3:52])[CH:26]=1)[C:17](=[O:19])[NH2:18])=O)C1C=CC=CC=1>CO.[C].[Pd]>[NH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:20][CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]2[C:33]([O:40][C@@H:41]3[O:49][C@H:48]([CH2:50][OH:51])[C@@H:46]([OH:47])[C@H:44]([OH:45])[C@H:42]3[OH:43])=[N:34][NH:35][C:36]=2[CH:37]([CH3:39])[CH3:38])=[C:27]([CH3:52])[CH:26]=1)[C:17](=[O:19])[NH2:18]