N,N-Dimethyl-1,3-propanediamine → N-[3-(dimethylamino)propyl]-2-nitrobenzenesulfonamide

Participants

Reaction Steps

To a solution of N,N-dimethyl-1,3-diaminopropane (0.92 g) and triethylamine (0.95 mL) in dichloromethane (10 mL) was added 2-nitrobenzenesulfonyl chloride (1 g), and the mixture was stirred at room temperature overnight. The reaction mixture was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=10/1) to give the title compound (1.26 g).

Provenance & Evidence