Benzenamine, 3-ethynyl- → (3-Ethynylphenyl)-(6-nitroquinazolin-4-yl)-amine Hydrochloride

Participants

Reaction Steps

4-Chloro-6-nitroquinazoline (1.06 g,5.00 mmol) and 3-ethynylaniline (1.00 g,5.30 mmol) were refluxed in 10 mL of isopropyl alcohol for 3 hours, cooled and, after 16 hours at room temperature, filtered to afford solid title product which was washed with 10 mL of isopropyl alcohol and dried in vacuo, at 70° C., 1.27 g (78%); mp 255°-256° C.

Provenance & Evidence