HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-ethynyl- → HCID 18925025, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | Methyl 4-chloroquinazoline-7-carboxylate | HCID 17750389 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | HCID 18925025 | HCID 18925025 | — |
Reaction Steps
4-Chloro-7-carbomethoxyquinazoline (202 mg, 0.907 mmol) and 3-ethynylaniline (110 mg, 0.939 mmol) were refluxed in 4 mL of tert-butyl alcohol for 2 hours, cooled, diluted with 4 mL of isopropyl alcohol and filtered to afford solid title product which was washed with 10 mL of diethyl ether and dried, in vacuo, at 70° C., 248 mg (80%); mp 219.5°-221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE041065E1 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-cb032eecc9ae4489812586f4cbaca589 |
| Source note | uspto-grants-2009_12 |