HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-ethynyl- → 6-O-Desmethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline | HCID 18925024 | — |
| Product | 6-O-Desmethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride | HCID 18925062 | — |
Reaction Steps
The title product was prepared from 4-chloro-6-(2-chloro-ethoxy)-7-(2-methoxyethoxy)-quinazoline (399 mg, 1.26 mmol) and 3-ethynyl-aniline (147 mg, 1.26 mmol) as described for Example 29. (515 mg; 94%; M.P. 215°-225° C. (dec); LC-MS: 398 (MH+); anal. RP18-HPLC RT: 4.85 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE041065E1 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-a95bdaecccae4d10b84982a5fa8566ad |
| Source note | uspto-grants-2009_12 |