HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → 1-{2-[4-(3-Ethynyl-phenylamino)-7-(2-methoxy-ethoxy)-quinazolin-6-yloxy]-ethyl}-1H-pyridin-4-one Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Piridin-4-one | HCID 17984897 | — |
| Reactant | 6-O-Desmethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride | HCID 18925062 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 1-{2-[4-(3-Ethynyl-phenylamino)-7-(2-methoxy-ethoxy)-quinazolin-6-yloxy]-ethyl}-1H-pyridin-4-one Hydrochloride | HCID 18925044 | — |
Reaction Steps
The free base of this product was prepared from the title product of Example 30 and the sodium salt of pyrid-4-one as described for Example 50. The free base was isolated by flash chromatography with 15% methanol/CHCl3 and converted to the title product according to the procedure described for Example 28 (32%; M.P. 155°-168° C. (dec); LC-MS: 457 (MH+); anal. RP-HPLC RT: 3.45 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE041065E1 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-c8f693869f4a4d07a0f7b4527e1ba1d2 |
| Source note | uspto-grants-2009_12 |