Tributylstannane → HCID 16664549, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Diethyl 3-[N-benzyloxy,N-(2-nitrobenzenesulfonyl)amino]-propynylphosphonate (109) (10.4 g, 21.6 mmol) and Tetrakis(triphenylphosphine)-palladium(0) (Pd(PPh3)4) (474 mg, 0.430 mmol) in dry THF (100 mL) was added tributyltin hydride (BU3SnH) (6.28 g, 21.6 mmol) over a period of 40 min at 0° C. The reaction mixture was stirred at 0° C. for one hour and was allowed to warm to room temperature over a period of time of 2 hours. The solvent was removed under reduced pressure and the crude oil was purified by column chromatography using a mixture of pentane/acetone (volume ratio 3/1), yielding 15 g of an amber oil (90%).

Provenance & Evidence