Water → HCID 57985885, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl-methyl]-malonic acid diethyl ester (1.0 g, 2.52 mmol) in a mixture of THF/EtOH (1/1, 24 ml) was added H2O (2 ml) followed by KOH (1.41 g, 25.2 mmol). The reaction mixture was stirred at 50° C. for 4 h, and then cooled to RT and concentrated. The solid residue was dissolved in H2O. The resulting solution was cooled to 0° C. and acidified to pH 4-5 by addition of HCl (I M). The white solid precipitate was collected by filtration, washed with cold H2O and dried to afford 2-[(4-Methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl-methyl]-malonic acid (809 mg, 94% yield).

Provenance & Evidence