Aluminium lithium hydride → HCID 57985892, compound

Participants

Reaction Steps

To a RT suspension of 3-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-methyl-3-phenyl-propionamide (155 mg, 0.50 mmol) in THF (5 mL) was slowly added LAH (1 M in THF, 1.5 mmol). The mixture was refluxed overnight, cooled to RT, and quenched by addition of freshly ground Na2SO4.10H2O. After stirring for 20 min, the solid was filtered off and washed with EtOAc (10 mL, 3 times) and DCM (10 mL, 2 times). The filtrate was concentrated, and the residue was purified via flash chromatography (DCM/MeOH/NH4OH) to afford [3-(4-Methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-phenyl-propyl]-methyl-amine as a white solid (90 mg, 61% yield).

Provenance & Evidence