Methylamine → HCID 57985926, compound

Participants

Reaction Steps

To a RT suspension of 3-pyridin-3-yl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-propionic acid (810 mg, 3.03 mmol) in DCM (30 mL) was added TEA (0.63 mL, 4.54 mmol) followed by PyBOP (1.73 g, 3.33 mmol) and MeNH2 (2 M in THF, 2.27 mL, 4.54 mmol). After stirring the reaction mixture at RT for 30 min, the beige precipitate was filtered off, and the filtrate was concentrated. The crude residue was purified via flash chromatography (DCM/MeOH/NH4OH) to afford N-Methyl-3-pyridin-3-yl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-propionamide as a yellow oil (525 mg).

Provenance & Evidence