Sodium Hydroxide → HCID 57985931, compound

Participants

Reaction Steps

To a RT solution of 2-[phenyl-(1H-pyrrolo[3,2-c]pyridin-3-yl)-methyl]-malonic acid diethyl ester (0.77 g) in EtOH (40 mL) was added NaOH (2 M in water, 15 ml). The mixture was stirred at reflux for 5 h, cooled to RT, and concentrated. The aqueous residue was acidified by addition of HCl (1 M) until dissolution. To this solution was added EtOAc resulting in precipitation of a solid, which was collected by filtration and dried, affording 2-[Phenyl-(1H-pyrrolo[3,2-c]pyridin-3-yl)-methyl]-malonic acid (341 mg, 52% yield).

Provenance & Evidence