4-Azaindole → HCID 59224307, compound

HRID 1869208Notes

Reaction equation

HRID 1869208 reaction equation
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[Cl:10][CH2:11][CH2:12][C@H:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)O>CO>[Cl:10][CH2:11][CH2:12][C@H:13]([N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 92264-AzaindoleHCID 642409(1R)-3-chloro-1-phenylpropan-1-ol

Product 1

HCID 59224307HCID 59224307, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(3-Chloro-1-(S)-phenyl-propyl)-1H-pyrrolo[3,2-b]pyridine was prepared from 1H-pyrrolo[3,2-b]pyridine and 3-chloro-1-(R)-phenyl-propan-1-ol following the procedure described in steps 1 and 2 of Example 11 (24% yield [268 mg, αD=−111.0° (MeOH, c=1)].

Sources & evidence

ORD record
ord-0ff7fcf62f394f32813c733bb91bca62
Source dataset
uspto-grants-2009_12
Patent number
US07638517B2

Reaction notes

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