4-Methoxy-1H-pyrrolo[2,3-b]pyridine → HCID 57985941, compound

HRID 1869215Notes

Reaction equation

HRID 1869215 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]2[NH:9][CH:10]=[CH:11][C:4]=12.[CH3:12][O:13][C:14](=[O:30])[C:15](=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17]>>[CH3:12][O:13][C:14](=[O:30])[CH:15]([CH:23]([N:9]1[C:5]2=[N:6][CH:7]=[CH:8][C:3]([O:2][CH3:1])=[C:4]2[CH:11]=[CH:10]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:16]([O:18][C:19]([CH3:21])([CH3:22])[CH3:20])=[O:17]

Participants

3

Reactant 2

HCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridineHCID 68557047HCID 68557047, compound

Product 1

HCID 57985941HCID 57985941, compound

Procedure

2-[(4-Methoxy-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methyl]-malonic acid tert-butyl ester methyl ester was prepared from 4-methoxy-1H-pyrrolo[2,3-b]pyridine (WO03/082289) and 2-benzylidene-malonic acid tert-butyl ester methyl ester using the procedure of Example 7, and was used without purification.

Workup

  1. customwas used without purification

Sources & evidence

ORD record
ord-20b65013e9fe4d42a80803fb145f3a44
Source dataset
uspto-grants-2009_12
Patent number
US07638517B2

Reaction notes

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