Trifluoroacetic acid → 2-{[1-(4-Chloro-phenyl)-2-cyclopropyl-2,7-diaza-spiro[3.5]nonane-7-carbonyl]-amino}-3-methyl-pentanoic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	(2S,3S)-2-Isocyanato-3-methylvaleric Acid Methyl Ester	HCID 7019165	—
Reactant	1,1-Dimethylethyl 1-(4-chlorophenyl)-2-cyclopropyl-2,7-diazaspiro[3.5]nonane-7-carboxylate	HCID 57986042	—
Product	2-{[1-(4-Chloro-phenyl)-2-cyclopropyl-2,7-diaza-spiro[3.5]nonane-7-carbonyl]-amino}-3-methyl-pentanoic acid methyl ester	HCID 68865733	—

Reaction Steps

Treat the compound from Example 2 with TFA according to the procedure of step D in Example 1 and treat the resultant product from this reaction with (2S,3S)-2-isocyanato-3-methylvaleric acid, methyl ester according to the procedure Example 1 step E to give the title compound which is characterized by LCMS. (MWT 448).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07638526B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-1d2e12d051a04b87bf29ae32721e8d41
Source note	uspto-grants-2009_12