Hydrochloric Acid → HCID 17984293, compound

Participants

Reaction Steps

2-(4-hydroxyphenyl)ethyl bromide (prepared as described in Acta Chem. Scand. 21 (1) 53-62, 1967) (3.4 g, 0.017 moles) and anhydrous potassium carbonate (4.6 g, 0.033 moles) in absolute ethanol (100 ml) were added to a solution of N-(4-piperidinylmethyl)-1-isopropyl-1H-3 indazolecarboxamide (4.2 g, 0.014 moles), prepared as described in EP-A-0 975 623 in absolute ethanol (80 ml). The suspension thus obtained was stirred continuously under reflux for 16 hours. The suspension was filtered and the filtrate evaporated under reduced pressure. The residue thus obtained was then transformed into the corresponding hydrochloride salt by dissolution in ethyl acetate, addition of ethanolic hydrogen chloride and recrystallisation from absolute ethanol to give the desired product (2.2 g).

Provenance & Evidence