HCID 53824934, compound → HCID 53827691, compound

HRID 1869238Notes

Reaction equation

HRID 1869238 reaction equation
[OH:1][C@@H:2]1[C@@H:7]([CH2:8][NH:9]CC2C=CC=CC=2)[CH2:6][CH2:5][N:4]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:3]1.[H][H]>CO.[Pd]>[NH2:9][CH2:8][C@H:7]1[CH2:6][CH2:5][N:4]([C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])[CH2:3][C@@H:2]1[OH:1]

Participants

5

Reactant 2

HCID 53824934HCID 53824934, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53827691HCID 53827691, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of intermediate (60) (0.016 mol) in methanol (150 ml) was hydrogenated with palladium-on-carbon (10%, 2 g) as a catalyst at a temperature of 50° C. After uptake of hydrogen (1 equivalent) the catalyst was filtered off and the filtrate was evaporated, yielding 1,1-dimethylethyl(3R-trans)-4-(aminomethyl)-3-hydroxy-1-piperidinecarboxylate (intermediate 61).

Workup

  1. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-9aaa055710844a509f6f8218b783e2b7
Source dataset
uspto-grants-2009_12
Patent number
US07638535B2

Reaction notes

Loading…