Trifluoroacetic acid → HCID 11429178, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1c (400 mg, 0.9 mmole) in CH2Cl2 (10 ml) at 0° C. is added TFA (10 ml) and the reaction is stirred for 1 h at 0° C. and a further hour at room temperature. Evaporating the solvents to dryness gave 1d (300 mg, 86%) as a white solid. 1H NMR (d6-DMSO) δ 9.34 (t, J=5.65 Hz, 1H), 8.20 (t, J=6.03 Hz, 1H), 7.89 (d, J=8.67 Hz, 2H), 7.56 (d, J=8.67 Hz, 2H), 7.43 (d, J=3.77 Hz, 1H), 7.05 (d, J=3.77 Hz, 1H), 4.63 (d, J=5.65 Hz, 2H), 3.59 (d, J=6.03 Hz, 2H).

Provenance & Evidence