Dimethylbarbituric acid → HCID 69038971, compound

Participants

Reaction Steps

A solution of the bisallylamine 2c (7.25 mmol), N,N′-dimethylbarbituric acid (NDMBA 2.8 g, 18.1 mmol), and Pd(PPh3)4 (148.8 mg, 0.13 mmol) in CH3Cl2 is degassed by bubbling argon for 10 min. The reaction mixture for 3 h at r.t. whereupon the desired amine 2d precipitates as its NDMBA salt. The mixture is diluted with EtOAc (200 ml) and hexane (200 ml) and washed with water (3×50 ml). The crude compound 2D is pure enough to be used in the next step without further purification.

Provenance & Evidence