HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → 3-(Dimethylamino)-1-(4-methylphenyl)-2-phenylprop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 1-(4-Methylphenyl)-2-phenylethan-1-one | HCID 228016 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(Dimethylamino)-1-(4-methylphenyl)-2-phenylprop-2-en-1-one | HCID 67218698 | — |
Reaction Steps
The solution of 1-(4-methylphenyl)-2-phenylethanone (1-1) (Renault, O; Dallemagne, P.; and Rault, S. Org. Prep. Proced. Int. 1999, 31, 324) (3.29 g, 15.65 mmol) and N,N-dimethylformamide dimethylacetal (4.66 g, 39.12 mmol) in DMF (15 mL) was stirred at 110° C. for 1 h. The mixture was concentrated in vacuo to give 3-(dimethylamino)-1-(4-methylphenyl)-2-phenylprop-2-en-1-one (1-2. LRMS m/z (M+H) Calcd: 266.4, found: 266.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07638530B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-544963cce72046beb6a601f042bf7f9d |
| Source note | uspto-grants-2009_12 |