Z-4-(2-Fluoro-3-methoxyphenyl)-4-methylpent-2-enoic acid methyl ester → 4-(2-Fluoro-3-methoxyphenyl)-4-methylpentanoic acid methyl ester

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Reaction Steps

23.30 g (84.33 mmol) of E/Z-4-(2-fluoro-3-methoxyphenyl)-4-methylpent-2-enoic acid methyl ester is mixed in 310 ml of ethanol with 1.2 g of palladium on carbon, and it is stirred under hydrogen atmosphere overnight at room temperature. The catalyst is removed by filtration through a glass-fiber filter, and the residue that remains after concentration by evaporation is chromatographed on silica gel (mobile solvent ethyl acetate/hexane). 19.58 g (83.4%) of the desired compound is isolated.

Provenance & Evidence