Boron tribromide → HCID 68679955, compound

HRID 1869382Notes

Reaction equation

HRID 1869382 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:19])([CH3:18])[CH2:9][C:10]([OH:17])([C:13]([F:16])([F:15])[F:14])[CH:11]=O)=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:22]=1[CH:23]=[N:24][NH:25]2.B(Br)(Br)Br>>[Cl:1][C:2]1[CH:7]=[C:6]2[C:5]([C:8]([CH3:19])([CH3:18])[CH2:9][C:10]([C:13]([F:16])([F:15])[F:14])([OH:17])[CH:11]2[NH:20][C:21]2[CH:29]=[CH:28][CH:27]=[C:26]3[C:22]=2[CH:23]=[N:24][NH:25]3)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 25134Boron tribromideHCID 413085NoName_3327HCID 21948865HCID 21948865, compound

Product 1

HCID 68679955HCID 68679955, compoundYield 6%

Procedure

Analogously to Example 2, the corresponding imine is produced starting from 350 mg of 4-(4-chlorophenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal and 158 mg of 4-aminoindazole. By reaction of 50 mg of imine with 1.8 ml of BBr3 (1N in dichloromethane), 29 mg of the title compound is obtained.

Sources & evidence

ORD record
ord-c34ae785de824291af6bec61785403ea
Source dataset
uspto-grants-2009_12
Patent number
US07638515B2

Reaction notes

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