HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthylamine → HCID 68679045, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthylamine | HCID 8640 | — |
| Reactant | 4-(2-Methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal | HCID 17989098 | — |
| Catalyst | Titanium isopropoxide | HCID 11026 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68679045 | HCID 68679045 | 77.7% |
Reaction Steps
150 mg (0.517 mmol) of 2-hydroxy-4-(2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-pentanal is converted into imine with 74 mg (0.517 mmol) of 1-naphthylamine in toluene with the aid of titanium tetraisopropylate. After working-up and chromatography, 166.7 mg (77.7%) of the desired imine is isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07638515B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-26edccf0578841f18a61809b52f5e35c |
| Source note | uspto-grants-2009_12 |