反应详情

A solution of 5-bromo-7-nitroindoline (5 g, 0.021 mol), 4-methoxyphenylsulfonyl chloride (6.36 g, 0.030 mol) in pyridine (10 ml) was stirred at 120° C. for 16 h. The reaction was quenched with water and extracted with CH2Cl2. The combined organic layer was dried over anhydrous MgSO4 and evaporated to give a residue that was chromatographed over silica gel (EtOAc:n-hexane=1:2) to afford compound 17, yield 85%.

1. customThe reaction was quenched with water
2. extractionextracted with CH2Cl2
3. dry with materialThe combined organic layer was dried over anhydrous MgSO4
4. customevaporated
5. customto give a residue that
6. customwas chromatographed over silica gel (EtOAc:n-hexane=1:2)