Propargyl alcohol → HCID 68665622, compound

HRID 1869557Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([O:24][C:25]([F:28])([F:27])[F:26])=[C:6]([C:8]2[CH:17]=[C:16]3[C:11]([C:12]([CH3:22])([CH3:21])[CH2:13][C:14](=[O:20])[N:15]3[CH2:18][CH3:19])=[CH:10][C:9]=2[CH3:23])[CH:7]=1.[CH2:29]([OH:32])[C:30]#[CH:31]>>[CH2:18]([N:15]1[C:16]2[C:11](=[CH:10][C:9]([CH3:23])=[C:8]([C:6]3[CH:7]=[C:2]([C:31]#[C:30][CH2:29][OH:32])[CH:3]=[CH:4][C:5]=3[O:24][C:25]([F:27])([F:28])[F:26])[CH:17]=2)[C:12]([CH3:21])([CH3:22])[CH2:13][C:14]1=[O:20])[CH3:19]

Participants

Reactant 2

HCID 7859Propargyl alcohol

HCID 68666441HCID 68666441, compound

Product 1

HCID 68665622HCID 68665622, compound

Procedure

Compound 57A was prepared from Compound 9B using a procedure similar to that described for Example 56A except that propargyl alcohol was used as the coupling partner. MS (electrospray): mass calculated for C24H24F3NO3, 431.45; m/z found 432.2, [M+H]+.

Sources & evidence

ORD record: ord-625fe05472e84e199b546716ca2fbd2d
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07638533B2

Reaction notes

Loading…