Maleic Acid → HCID 86619555, compound

Participants

Reaction Conditions

Reaction Steps

1.0 g (1.39 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate are dissolved in 10 ml of ethanol at ambient temperature and combined with 322 mg (2.78 mmol) maleic acid. The mixture is heated to 70° C., during which time a white precipitate is formed. The suspension is cooled to ambient temperature over 8 hours and filtered at 5° C. The isolated crystals are dried for 12 hours at 50° C.

Provenance & Evidence