Hydrogen Bromide → HCID 69061257, compound

Participants

Reaction Conditions

Reaction Steps

0.5 g (0.69 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate are dissolved in 5 ml of ethanol at ambient temperature and combined with 78 μl hydrobromic acid (48% in water). The mixture is heated to 70° C., whereupon a light yellow solution is formed. This solution is stirred for 3 days at 50° C., during which time a white precipitate is formed. After cooling to ambient temperature the solid formed is filtered off and dried for 12 hours at 40° C.

Provenance & Evidence