Fumaric Acid → HCID 86619557, compound

Participants

Reaction Conditions

Reaction Steps

2.5 g (2.95 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate are dissolved in 25 ml of ethanol at ambient temperature, combined with 685 mg (5.9 mmol) fumaric acid and heated to 45° C. A viscous suspension is formed, which is diluted by the addition of 15 ml of ethanol. The mixture is heated to 70° C., during which time a white precipitate is formed. The suspension formed is diluted with another 5 ml of ethanol, cooled to 26° C. and filtered. The isolated solid is dried for 12 hours at 60° C.

Provenance & Evidence