Hydrogen Bromide → HCID 69058106, compound

Participants

Reaction Conditions

Reaction Steps

0.5 g (0.79 mmol) 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-(1R)-1-[(4-hydroxy-3,5-dimethylphenyl)methyl]-2-[4-(4-morpholinyl)-1-piperidinyl]-2-oxoethyl 1-piperidinecarboxylate are suspended in 5 ml n-propanol at ambient temperature and heated to 70° C. After the addition of 157 μl hydrobromic acid (30% in glacial acetic acid) the mixture is stirred for 1 hour at 70° C. and 20 hours at 40° C. Then the suspension formed is cooled to ambient temperature, stirred for 5 hours and filtered. The residue is dried for 4 hours at 80° C.

Provenance & Evidence