Hydrochloric Acid → HCID 69061225, compound

Participants

Reaction Steps

0.5 g (0.79 mmol) 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-(1R)-1-[(4-hydroxy-3,5-dimethylphenyl)methyl]-2-[4-(4-morpholinyl)-1-piperidinyl]-2-oxoethyl 1-piperidinecarboxylate are dissolved in 5 ml of ethanol at ambient temperature and combined with 65.3 μl hydrochloric acid (37% in water). After 2 hours at ambient temperature tert-butylmethylether is added dropwise until turbidity sets in. After another 2 hours at ambient temperature the white precipitate formed is filtered off, washed with tert-butyl-methylether and dried for 12 hours at 40° C.

Provenance & Evidence