Phosphoric Acid → HCID 69063038, compound

Participants

Reaction Conditions

Reaction Steps

1.0 g (1.58 mmol) 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-(1R)-1-[(4-hydroxy-3,5-dimethylphenyl)methyl]-2-[4-(4-morpholinyl)-1-piperidinyl]-2-oxoethyl 1-piperidinecarboxylate are dissolved in 8.9 ml boiling ethanol and combined with a solution of 106 μl phosphoric acid (85% in water) in 1.06 ml of ethanol. The mixture is stirred for 2 hours at 72° C., whereupon a white suspension is formed. After cooling the suspension is stirred for 12 hours at ambient temperature. The crystals formed are filtered off and dried for 12 hours at 40° C.

Provenance & Evidence