Hydrochloric Acid → HCID 68824731, compound

Participants

Reaction Steps

3.0 g (4.2 mmol) (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-1-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butane-1,4-dione are dissolved in 3 ml acetone and combined with a solution of 4.2 ml hydrochloric acid (1 mol/l in water) in 22.8 ml of water. The mixture is refluxed and cooled to ambient temperature within 12 hours. The solid formed is filtered off and dried for 12 hours at 40° C.

Provenance & Evidence