Hydrogen Bromide → HCID 68825644, compound

Participants

Reaction Conditions

Reaction Steps

2.0 g (2.6 mmol) (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-1-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butane-1,4-dione are dissolved in 20 ml isopropanol and at 50° C. combined with 0.6 ml hydrobromic acid (47% in water). The mixture is cooled to 4° C. within 30 minutes. The solid formed is filtered off, washed with 5 ml cold isopropanol and dried for 12 hours at 40° C.

Provenance & Evidence