Methanol → 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide p-toluenesulphonate

Participants

Reaction Steps

0.2 g (0.30 mmol) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide and 57.8 mg (0.30 mmol) p-toluenesulphonic acid are suspended in 10 ml acetone and refluxed. 1 ml of methanol is added to this suspension, whereupon the substance goes into solution completely. After cooling to ambient temperature the solid formed is filtered off, washed with acetone and dried for 12 hours at 40° C.

Provenance & Evidence