Benzenesulfonic Acid → 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide benzenesulphonate

Participants

Reaction Conditions

Reaction Steps

1.0 g (1.52 mmol) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide and 240 mg (1.52 mmol) benzenesulphonic acid are dissolved in 14 ml boiling isopropanol. The solution is stirred for 24 hours at 50° C. Then the temperature is reduced by 5° C. every 8 hours, during which time a white precipitate is formed. After 3 days and at a final temperature of 25° C. the solid formed is filtered off, washed with 5 ml isopropanol and dried for 12 hours at 50° C.

Provenance & Evidence