1,5-Naphthalenedisulfonic acid → 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide naphthalene-1,5-disulphonate

Participants

Reaction Conditions

Reaction Steps

A solution of 1.427 g naphthalene-1,5-disulphonic acid (4.95 mmol) in 70 ml isopropanol is added to 3.25 g (4.94 mmol) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide and heated to 80° C. The now clear solution is cooled to ambient temperature, by lowering the temperature of the heating bath by 5° C. every 6 hours. The resultant suspension is filtered, the isolated solid is dried for 12 hours at 40° C.

Provenance & Evidence