HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzimidazole → HCID 178495389, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzimidazole | HCID 5798 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 178495390 | HCID 178495390 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 178495389 | HCID 178495389 | — |
| Product | HCID 178495390 | HCID 178495390 | — |
Reaction Steps
PCT Application PCT/GB2004/000064 and International Publication Number WO 2004/063188 A1, discloses the preparation of rabeprazole and benzimidazole type of compounds. Accordingly, rabeprazole base is prepared by oxidation using sodium hypohalites and isolated. Rabeprazole sodium is prepared by dissolving rabeprazole base in ethylacetate and methanolic ammonia mixture to which methanolic sodium hydroxide is added. The solvent is distilled and rabeprazole sodium is isolated from ethylacetate and n-heptane/n-hexane mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07638633B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-01389cdce6cb4e38ac51b1c46ea960b8 |
| Source note | uspto-grants-2009_12 |