HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → 1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Piperidin-4-ylmethyl-piperidine-1-carboxylic acid t-butyl ester | HCID 49761197 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate | HCID 68886952 | — |
Reaction Steps
1,1-Dimethylethyl 4-(4-piperidinylmethyl)-1-piperidinecarboxylate (may be prepared as described in Description 2) (2 g), ethyl iodide (0.57 ml) and K2CO3 (1.96 g) were combined in acetonitrile (70 ml) and the reaction mixture was stirred at room temperature for 3 h. The reaction was filtered to remove solids and the solvent evaporated to give the title compound (D7) as a yellow solid (2.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07638631B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-9d9a8c3bbd3b4bbb829e5f99c081bf2a |
| Source note | uspto-grants-2009_12 |