反应详情

1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate (may be prepared as described in Description 7) (2.5 g) was stirred in a solution of HCl-Dioxane (70 ml, 4M) for 2 h. The solvent was evaporated and the resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into DCM (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D8) (1.48 g).

1. customThe solvent was evaporated
2. dissolutionthe resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml)
3. extractionThe solution was extracted into DCM (3×50 ml)
4. dry with materialthe combined organics dried (MgSO4)
5. customevaporated