1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate → 1-(Cyclopropylmethyl)-4-(4-piperidinylmethyl)piperidine

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Reaction Steps

1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate (may be prepared as described in Description 9) (2.0 g) was stirred in a solution of HCl-Dioxane (700 ml, 4M) for 2 h. The solvent was evaporated and the resultant yellow solid was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D10) (1.0 g).

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