反应详情

1,1-Dimethylethyl 4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate (may be prepared as described in Description 3) (3.1 g) was stirred in a solution of HCl-Dioxane (50 ml, 4M) for 2 h. The solvent was evaporated and the product was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (Na2SO4) and evaporated to give the title compound (D19) (0.658 g).

1. customThe solvent was evaporated
2. dissolutionthe product was dissolved in saturated potassium carbonate (25 ml)
3. extractionThe solution was extracted into dichloromethane (3×50 ml)
4. dry with materialthe combined organics dried (Na2SO4)
5. customevaporated