Lithium Hydroxide → HCID 68419034, compound

Participants

Reaction Steps

A solution of methyl{1-(4-chlorophenyl)-2-[4(trifluoromethyl)phenyl]piperidine-4-yl}acetate (34 mg, 0.08 mmol) in THF (2 ml) and H2O (2 ml) was treated with LiOH (19 mg, 0.8 mmol) and the mixture was stirred at room temperature for 20 hours. The reaction was diluted with hydrochloric acid (1N, 20 ml) and extracted with EtOAc (2×20 ml). The combined extracts were washed with brine (×1), then dried (MgSO4), filtered and evaporated. The residue was purified by chromatography on silica, eluting with 7.5% MeOH/DCM give the acid as a clear gum (15 mg, 45%). 1H NMR (400 MHz, CD3OD) δ: 1.34-1.40 (1H, m), 1.54-1.67 (1H, m), 1.84-2.12 (3H, m), 2.24-2.30 (2H, m), 2.86 (1H, dt, J 12.1, 2.4), 3.47-3.54 (1H, m), 4.15 (1H, dd, J 11.5, 2.7), 6.95 (2H, d, J 8.8), 7.06 (2H, d, J 8.8), 7.44 (4H, s).

Provenance & Evidence