Hydrochloric Acid → HCID 69240668, compound

Participants

Reaction Steps

A mixture of the pyridine from Step 1 (270 mg, 0.77 mmol) platinum (IV) oxide (30 mg) and HCl solution (4N in dioxan, 0.2 ml, 0.8 mmol) in MeOH (15 ml) was hydrogenated at 20 psi on a Parr® apparatus for 0.5 hours. The catalyst was removed by filtration and the filtrate evaporated in vacuo. The residue was purified by chromatography on silica, eluting with 1-2% 2M NH3 in MeOH/DCM to give the title compound (168 mg, 61%) as an oil The give the desired piperidine as white solid (7.1 g, quant). M/Z (ES+) 348 (MH+). The product was contaminated with a small amount of over reduced material: M/Z (ES+) 362 (MH+).

Provenance & Evidence