Sodium Hydroxide → HCID 57987478, compound

Participants

Reaction Conditions

Reaction Steps

The ester from Step 1 (100 mg) was dissolved in methanol (1 mL) and sodium hydroxide (0.3 mL, 4N) was added. The mixture was heated at 60° C. overnight, cooled, evaporated and the residue dispersed between CH2Cl2 and HCl (0.1N). The organic extract was separated and washed with brine, dried (MgSO4) and evaporated. The residue was purified on silica using 10-95% ethyl acetate in iso-hexane as eluant.

Provenance & Evidence