HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-bromo-4-(trifluoromethyl)- → {(2s,4r)-1-{Bis[4-(trifluoromethyl)phenyl]methyl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reactant | (+)-methyl{(2S,4R)-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate | HCID 86617999 | — |
| Product | {(2s,4r)-1-{Bis[4-(trifluoromethyl)phenyl]methyl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetic acid | HCID 57987491 | — |
Reaction Steps
The compound was prepared analogously to Example 160 using the Grignard reagent derived from 4-brombenzotrifluoride and starting with the chiral piperidine of Example 114 Step 1. M/Z (ES+) 590 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07638629B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-067acc28a9ce4bf291ae259f7456294c |
| Source note | uspto-grants-2009_12 |