Methanol → Methyl 2-amino-3-(4-nitrophenyl)propanoate

Participants

Reaction Steps

To a suspension of 4-nitrophenylalanine 1 (25 g) in methanol (10 ml/g) at 0° C. is added SOCl2 (2 equ.). After 30 minutes, the reaction is stirred at room temperature for 1 night. Volatiles are then evaporated and the residue is diluted in water. The solution is alkalinized with NaOH 2N and extracted with CH2Cl2. The organic phase is dried over MgSO4 and evaporated. No further purification is needed.

Provenance & Evidence