反应详情

To a solution of methyl 2-[(tert-butoxycarbonyl)amino]-3-(4 nitrophenyl)propanoate 3 (69.4 g) and NH4HCO2 (6.5 equ.) in CH3OH (20 ml/g) is added 5% Pd/C (15% in weight, 10 g). The temperature rises to 40° C. and then decreases. After stirring for 2 h at room temperature, the solution is filtered over celite and the solvent is evaporated. The residue is diluted in AcOEt and washed 3 times with water. The organic phase is dried over MgSO4 and evaporated to dryness. No further purification is needed.

1. customrises to 40° C.
2. filtrationthe solution is filtered over celite
3. customthe solvent is evaporated
4. additionThe residue is diluted in AcOEt
5. washwashed 3 times with water
6. dry with materialThe organic phase is dried over MgSO4
7. customevaporated to dryness
8. customNo further purification